The Study on Antioxidation and Mechanism of 2 - Bromo - 4'- Nitroacetophenone

Abstract

The 2-Bromo-4'-nitroacetophenone is an important compound which is widely used in the modification of methionine residues in alpha-chymotrypsin, organic synthesis materials and pharmaceutical intermediates. Our laboratory recently found that the 2-bromo-4'-nitroacetophenone can extend the lifespan of the C. elegans. Therefore, we want to know whether this compound has the anti-oxidative ability.

In this paper, we used three different concentrations of 2-bromo-4'-nitroacetophenone to feed normal C. elegans and the mutants (daf-16). we found that 2-bromo-4'-nitroacetophenone has antioxidant effect and this effect is dependent on Insulin pathway.