The Study on Antioxidation and Mechanism of 2 - Bromo - 4'- Nitroacetophenone

Runze Han

Abstract


The 2-Bromo-4'-nitroacetophenone is an important compound which is widely used in the modification of methionine residues in alpha-chymotrypsin, organic synthesis materials and pharmaceutical intermediates. Our laboratory recently found that the 2-bromo-4'-nitroacetophenone can extend the lifespan of the C. elegans. Therefore, we want to know whether this compound has the anti-oxidative ability.

In this paper, we used three different concentrations of 2-bromo-4'-nitroacetophenone to feed normal C. elegans and the mutants (daf-16). we found that 2-bromo-4'-nitroacetophenone has antioxidant effect and this effect is dependent on Insulin pathway.


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DOI: https://doi.org/10.5296/jbls.v9i2.12819

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Copyright (c) 2018 Runze Han

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Journal of Biology and Life Science  ISSN 2157-6076

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